A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications

Bacterial cellulose (BC) is a good material candidate for wound dressing because of its fine 3-D network structure, high mechanical strength and water holding capability, biocompatibility. In this study, composite hydrogel was prepared by using 1,4-butanediol diglycidyl ether (BDDE) to cross-link BC hyaluronic acid (HA). Cross-linked BC/HA composites exhibited denser smoother surface. This dense morphology improved retention capability dimensional stability. BDDE cross-linked with 2% HA 1% showed better overall properties, including stability (12.7 % solubility), properties (tensile strength: ? 0.61 MPa Young’s modulus: ?1.62 MPa) thermal (maximum degradation temperature: 360 °C), as compared without crosslinking. addition, cell toxicity assays indicated the significantly promoted proliferation adhesion. chemically may have many new biomedical applications in care.